Antihistaminic Drugs for Inhibiting Untoward Reactions to Injections of Contrast Medium

Atherosclerosis; inhibiting effect of an antihistaminic drug, chlorpheniramine.

• Atherosclerotic lesions tend to form in areas of the vascular tree subjected to injury —usually mechanical injury. Since injury enhances the phagocytic activity of endothelial cells,' the possibility arises that localization of lipid material may be due in part to phagocytosis of serum lipoproteins by injury-activated aortic endothelial cells. Supporting this possibility is the observation th...

Rapid desensitization for hypersensitivity reactions to chemotherapeutic drugs; a case series

Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is e...

Rapid desensitization for hypersensitivity reactions to chemotherapeutic drugs; a case series

Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is e...

Injections of Contrast

Background. Myocardial opacification during echocardiography has been demonstrated after left (LA) and right (RA) atrial injections of contrast, and microvascular damage with reduced blood flow and impaired flow reserve has been documented in necrotic myocardial tissue. Therefore, we hypothesized that because of its ability to depict capillary perfusion, myocardial contrast echocardiography (MC...

Allergic reactions to drugs.